Endocrine Abstracts

Background Comprehensive evaluation of the effect of surgery in patients with primary hyperparathyroidism (PHPT) and monitoring of patient’s well-being after treatment including assessment of patient-reported outcomes is worthwhile.AIMWe aimed to assess changes in quality of life (QoL) and symptoms in patients with symptomatic and asymptomatic PHPT after surgery (parathyroidectomy, PTX).Materials and methods.Adult patients wit...

Primary hyperparathyroidism (PHPT) is a complex endoctinopathy that involves parathyroid glands which secreting too much parathyroid hormone and due to causes hypercalcemia effecting different organs and leading to significant quality of life (QoL) impairment. QoL assessment before and after surgery in patients with PHTP may be useful for comprehensive evaluation of the treatment effect, as well as for monitoring of the patient’ condition after surgery, including in real ...

Introduction: Prolonged QTc interval is a known risk factor for developing ventricular tachyarrhythmias. QTc prolongation is often reported in patients with pheochromocytoma, however the literature data on this issue are rather heterogeneous. Here we report the results of QTc measurement in patients with pheochromocytoma and paraganglioma (PPGL) in comparison to hormonally inactive benign adrenal tumors.Methods: The test group included 204 patients with ...

In 2000 female, 28 y.o., admitted endocrinologist with headache, high blood pressure, dark skin and muscle weakness. Lab data showed high levels of ACTH and cortisol, low potassium level. According to MRI scans, pituitary gland seemed normal. On CT in right adrenal was found 32 mm mass with the native density of 20 HU. Diagnosed ACTH-dependent Cushing syndrome (CS). As Mitotane was not available in Russia at that time, she received ketokonazole due to progression of CS but it ...

Background: A parathyroidectomy (PTX) is the preferred standard treatment for patients with primary hyperparathyroidism (PHPT). the assessment of the surgery success from patient’s perspective is important to provide patient-centered care.Aim: We aimed to evaluate QoL changes in PHPT patients during 2-years follow-up after PTX and to identify preoperative predictors of meaningful QoL improvement after surgery.Materials and Met...

Background: It is disputable whether to repeat FNAB after the first one was nondiagnostic, or to submit the patient to operation.Methods: Indication for FNAB was a thyroid nodule of ≥1 cm or of a less size with clinical or ultrasound features of malignancy. In case of multinodular goiter each nodule was punctured and examined separately.3929 cases (8%) were noninformative out of 49 419 FNAB of thyroid nodules performed in Nor...

Background: Fine needle aspiration biopsy is generally acknowledged as a «gold standard» for diagnostics of thyroid malignancies. However, data on FNAB vary considerably in publications from different centers. In this study we have analyzed the results of more than 40 000 FNAB of thyroid nodules performed in North-West Regional Endocrine Center during 2010–2012 years.Subjects and methods: Indication for FNAB was a thyroid nodule of ≥...

Background: Unintented parathyroidectomy during thyroid surgery – is one of typical complications, especially when an operation is augmented by lymphodissection. In this work, we present the results of calcium metabolism analysis in such patients.Subjects and methods: 3929 operations of patients with different thyroid diseases were performed during 2010–2012 years. 82 inadvertently excised parathyroid glands were revealed at histological examin...